Procoagulant tumor microvesicles attach to endothelial cells on biochips under microfluidic flow
نویسندگان
چکیده
منابع مشابه
Placement Algorithm for Flow-Based Microfluidic Biochips
Microfluidic biochips revolutionize biology by placing laboratory functionality on a very small chip. The subject of this thesis is a flow-based biochip, which consists of thin channels in which fluids flow. The basic building block of the chip is a valve, which can direct the flow by blocking or unblocking channels. The valves are combined to create components like switches, mixers, and mul-ti...
متن کاملFault Tolerant DNA Computing Based on Digital Microfluidic Biochips
Historically, DNA molecules have been known as the building blocks of life, later on in 1994, Leonard Adelman introduced a technique to utilize DNA molecules for a new kind of computation. According to the massive parallelism, huge storage capacity and the ability of using the DNA molecules inside the living tissue, this type of computation is applied in many application areas such as me...
متن کاملDigital-Microfluidic Biochips
D igital-micro uidic biochips (DMFBs) are revolutionizing laboratory procedures for point-of-care clinical diagnostics, environmental monitoring, and drug discovery. DMFBs allow bioassay protocols to be scaled down to droplet size. They’re executed by enabling precise control of discrete droplets using a patterned array of electrodes. Biochemistry’s inherent complexity means that operational er...
متن کاملCD11b/CD18-coated microspheres attach to E-selectin under flow.
Neutrophils can attach to E-selectin under flow. Proposed ligands for E-selectin carry SLe(x)-type glycans. The leukocyte beta2 integrins are glycosylated with SLe(x). Thus, we speculated that beta2 integrins could support attachment to E-selectin. To test this hypothesis, we coated 10-microm-diameter microspheres with purified CD11b/CD18 (alphaMbeta2) and investigated the adhesion of the resul...
متن کاملModeling and Simulation of Procoagulant Circulating Tumor Cells in Flow
We describe a mathematical/computational model for thrombin concentration gradients generated by procoagulant circulating tumor cells (CTCs) in flow. We examine how CTCs enhance blood coagulation as they diffuse tissue factor-dependent coagulation enzymes in a flow environment with vessel walls. Concentration fields of various enzymes, such as prothrombin and thrombin, diffuse, to, and from CTC...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomicrofluidics
سال: 2019
ISSN: 1932-1058
DOI: 10.1063/1.5123462